![]() Case PresentationĪ 43-year-old left-handed male working in finance presented to the emergency room (ER) with transient global anterograde and retrograde amnesia 22 days after sustaining a concussion. ![]() We present a case report of a 43-year-old male with TGA following mild traumatic brain injury (mTBI), with evidence supporting the role of mTBI as a precipitating event facilitating the pathophysiological cascade of TGA. Furthermore, few studies have investigated TGA in the context of concussion and the clinical sequelae following TGA. Although clinical characteristics of TGA have been studied for over 50 years, true etiology remains unknown. Proposed mechanisms include vascular (e.g., venous flow disturbances or focal arterial ischemia), epileptic, hypoxic, or migraine-related pathogenesis ( 1). The annual incidence of TGA is 3.4–10.4 per 100,000 people ( 1). Transient global amnesia (TGA) is a rare clinical syndrome, which affects predominantly patients aged 50–70 years, characterized by an acute onset of anterograde and retrograde amnesia, often accompanied by repetitive questioning, lasting up to 24 h, and not associated with other neurological deficits. We suggest that a lingering window of post-concussion cerebral vulnerability, which may extend beyond clinical recovery, could lead to increased susceptibility to acute cognitive deficits, such as TGA. The patient remained symptomatic for 32 days after the TGA episode. Following the TGA episode, the patient experienced notable worsening of concussive symptoms, including headache, head pressure, anxiety, neck pain, feeling slowed down, fogginess, not feeling right, difficulty remembering, and fatigue. The patient's head CT, MRI of brain, and EEG were reported normal, and the patient regained full cognitive function 8 h after the TGA episode, with no recollection of the conspiring events. Here we review the case of a 43-year-old male with onset of transient global anterograde and retrograde amnesia 22 days after a sustained concussion. ![]() Department of Neurology, Hospital for Special Surgery, New York, NY, United Statesįew studies have investigated transient global amnesia (TGA) in the context of a concussion and the concussion sequelae following TGA.
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